Publications previous to 2015

 Click here for current publications


Matkovich SJ*, Edwards JR, Grossenheider TC, de Guzman Strong C, Dorn GW, 2nd *. Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs. Proc Natl Acad Sci USA. 2014;111:12264-9. 
* co-corresponding authors

Chen S, Puthanveetil P, Feng B, Matkovich SJ, Dorn GW, II, Chakrabarti S. Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes. J Cell Mol Med. 2014;18:415-21.

Chen Y, Sparks M, Bhandari P, Matkovich SJ, Dorn GW, II. Mitochondrial genome linearization is a causative factor for cardiomyopathy in mice and Drosophila. Antioxid Redox Signal. 2014;21:1949-59.

Vijayakumar R, Silva JN, Desouza KA, Abraham RL, Strom M, Sacher F, Van Hare GF, Haïssaguerre M, Roden DM, Rudy Y. Electrophysiologic substrate in congenital Long QT syndrome: noninvasive mapping with electrocardiographic imaging (ECGI). Circulation. 2014 Nov 25;130(22):1936-43. PMCID: PMC4245321.

Lindman BR, Pibarot P, Arnold SV, Suri RM, McAndrew TC, Maniar HS, Zajarias A, Kodali S, Kirtane AJ, Thourani VH, Tuzcu EM, Svensson LG, Waksman R, Smith CR, Leon MB. Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Diabetes and Severe Aortic Stenosis at High Risk for Surgery: An Analysis of the PARTNER Trial (Placement of Aortic Transcatheter Valve). J Am Coll Cardiol. 2014 Mar 25;63(11):1090-9. PMID: 24291272;PMCID: PMC3962709.

Weber K, Schilling JD. Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation. J Biol Chem. 2014 Mar 28;289(13):9158-71. PMID: 24532802; PMCID: PMC3979407.

Soufi N, Hall AM, Chen Z, Yoshino J, Collier SL, Matthews JC, Brunt EM, Albert CV, Graham MJ, Ford DA, and Finck BN. 2014. Inhibiting monoacylyglycerol acyltransferase 1 reduces hepatic triacylgycerol content, but not inflammation and injury in mice. J. Biol. Chem. 289:30177-30188. [PMCID: PMC4208022].

Arnold SV, Spertus JA, Lipska KJ, Tang F, Goyal A, McGuire DK, Cresci S, Maddox RM, Kosiborod M. Association between diabetes mellitus and angina after acute myocardial infarction: analysis of the TRIUMPH prospective cohort study. Eur J Prev Cardiol. 2014; PMCID: PMC4199926

Sleder A, Li J, Cassidy-Bushrow A, Cresci S, Williams K, Sabbah HN, Lanfear DE. Genomic loci evaluation with albuminuria in new-onset insulin dependent diabetics. Journal of Pharmacogenomics and Pharmacoproteomics. 2014; 5:122. doi: 10.4172/2153-0645.1000122


Kadkhodayan A, Coggan AR, Peterson LR. A "PET" area of interest: myocardial metabolism in human systolic heart failure. Heart Fail Rev. 2013 Sep;18(5):567-74. Review. PMID: 23180281; PMCID: PMC3740208.

Riek AE, Oh J, Bernal-Mizrachi C. 1,25(OH)2 vitamin D suppresses macrophage migration and reverses atherogenic cholesterol metabolism in type 2 diabetic patients. J Steroid Biochem Mol Biol. 2013 Jul;136:309-12. Review. PMID: 23333932; PMCID: PMC3687029.

Martel C, Li W, Fulp B, Platt AM, Gautier EL, Westerterp M, Bittman R, Tall AR, Chen SH, Thomas MJ, Kreisel D, Swartz MA, Sorci-Thomas MG, Randolph GJ. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. J Clin Invest. 2013 Apr 1;123(4):1571-9. PMID: 23524964.

Role of Fat Body Lipogenesis in Protection against the Effects of Caloric Overload in Drosophila. Musselman LP, Fink JL, Ramachandran PV, Patterson BW, Okunade AL, Maier E, Brent MR, Turk J, Baranski TJ. J Biol Chem. 2013 Mar 22;288(12):8028-42. PMID: 23355467. Schilling JD, Machkovech H, He L, Diwan A, Schaffer JE. TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death Through a TRIF-Dependent Pathway. J Immunol. 2013. Feb;190(3). PCMID: 23275600

Schilling JD, Machkovech H, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, and Schaffer, JE. Palmitate and LPS trigger Synergistic Ceramide Production in Primary Macrophages. J Biol Chem. 2013. 2013 Feb 1;288(5):2923-32. PCMID: 23250746

A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. Pendse J, Ramachandran PV, Na J, Narisu N, Fink JL, Cagan RL, Collins FS, Baranski T. BMC Genomics. 2013 Feb 27;14:136. PMID: 23445342.

A Drosophila model of high sugar diet-induced cardiomyopathy. Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R. PLoS Genet. 2013 Jan;9(1):e1003175. PMID: 23326243.

Cotter DG, Schugar RC, Crawford PA. Ketone body metabolism and cardiovascular disease. Amer J Physiol Heart Circ. 2013; 304:H1060-76.

LaHusen-Bair S, Coggan AR, Bashir A, Farmer M, O’Connor RD, Anderson-Spearie C, Waggoner AD, Woodard P, Javidan-Nejad C, Banan B, Krupp K, Dávila-Román VG, Peterson LR. A diet high in long chain fatty acids worsens systolic function in patients with type 2 diabetes, but a diet rich in medium chain fatty acids does not: a randomized, double-blind study Journal of the American College of Cardiology 2013;61(10_S).

Karrowni W, Li Y, Jones PG, Cresci S, Abdallah M, Lanfear DE, Maddox TM, McGuire DK, Spertus JA, Horwitz PA. Insulin resistance is associated with significant clinical atherosclerosis in non-diabetic patients with acute myocardial infarction. Arterioscler Thromb Vasc Biol. 2013; 33:2245-2251. PMCID: PMC3855677


Schilling JD, Machkovech H, Kim A, Schwendener, R, and Schaffer JE. Macrophages Modulate Cardiac Function in Lipotoxic Cardiomyopathy. Am J Physiolo Heart Circ Physiol. 2012. Dec;303(11):H1366-73. PCMID: 23042950.

Riek AE, Oh J, Sprague JE, Timpson A, de las Fuentes L, Bernal-Mizrachi L, Schechtman KB, Bernal-Mizrachi C. Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients. J Biol Chem. 2012 Nov 9;287(46):38482-94. PMID: 23012375; PMCID: PMC3493893.

Scruggs BS, Michel CI, Ory DS, Schaffer JE. SmD3 regulates intronic noncoding RNA biogenesis. Mol Cell Biol. 2012 Oct;32(20):4092-103. Epub 2012 Aug 6. PMID: 22869524; PMCID: PMC3457340.

Schilling JD and Mann DL. Diabetic Cardiomyopathy: Bench to Bedside. Heart Fail Clin. 2012. Oct;8(4):619-31. PMCID:22999244

Schilling JD, Mann DL. Diabetic cardiomyopathy: bench to bedside. Heart Fail Clin. 2012 Oct;8(4):619-31. PMID: 22999244;PMCID: PMC3457018.

Schilling JD, Machkovech H, Kim AH, Schwendener R, Schaffer JE. Macrophages Modulate Cardiac Function in Lipotoxic Cardiomyopathy. Am J Physiol Heart Circ Physiol. 2012 Oct 5. [Epub ahead of print] PubMed PMID: 23042950.

Gautier EL, Chow A, Spanbroek R, Marcelin G, Greter M, Jakubzick C, Bogunovic M, Leboeuf M, van Rooijen N, Habenicht AJ, Merad M, Randolph GJ. Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity. J Immunol. 2012 Sep 1;189(5):2614-24. PMID: 22855714.

Kiebish MA, Yang K, Sims HF, Jenkins CM, Liu X, Mancuso DJ, Zhao Z, Guan S, Abendschein DR, Han X, Gross RW. Myocardial Regulation of Lipidomic Flux byCardiolipin Synthase: SETTING THE BEAT FOR BIOENERGETIC EFFICIENCY. J Biol Chem. 2012 Jul 20;287(30):25086-97. PMID: 22584571.

Oh J, Riek AE, Weng S, Petty M, Kim D, Colonna M, Cella M, Bernal-Mizrachi C. Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation. J Biol Chem. 2012 Feb 22. PMID: 22356914.

Lindley KJ, RavichandranAK, Schilling JD, Joseph SM. MD Antibody Mediated Rejection of the Heart in the Setting of Autoimmune Demyelinating Polyneuropathy: A Case Report and Review of the Literature. Case Reports in Cardiology. Case Reports in Cardiology, vol. 2012, Article ID 639284, 4 pages, 2012. doi:10.1155/2012/639284.

Oh J, Riek AE, Weng S, Petty M, Kim D, Colonna M, Cella M, Bernal-Mizrachi C. Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation. J. Biol. Chem., 287(15):11629-11641, 2012. PMCID: PMC3320.9.

Liu S, Xie Z, Zhao Q, Pang H, Turk J, Calderon L, Su W, Zhao G, Xu H, Gong MC, & Guo Z. Smooth muscle-specific expression of iPLA2β participates in the initiation and early progression of vascular inflammation and neointima formation. J. Biol. Chem. 2012; 287: 24739-53. PMID: 22637477.

Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Hsu FF, Turk J, & Semenkovich CF. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Cell Metab. 2012; 16: 189-201. PMID: 22863804.

E. L. Gautier, T. Shay, J. Miller, M. Greter, C. Jakubzick, J. Helft, A. Chow, K. G. Elpek, S. Gordonov, A. R. Mazloom, W-J Chua, T. H. Hansen, A. Ma’ayan, S. J. Turley, M. Merad, G. J Randolph. 2012. Gene expression profiles and transcriptional regulatory pathways underlying murine tissue macrophage identity and diversity. Nat. Immunol. 13:118-1128.


Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide Mononucleotide, a Key NAD(+) Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice. Cell Metab. 2011 Oct 5;14(4):528-36. PMID: 21982712.

Lin CH, Kurup S, Herrero P, Schechtman KB, Eagon JC, Klein S, Dávila-Román VG, Stein RI, Dorn Ii GW, Gropler RJ, Waggoner AD, Peterson LR. Myocardial oxygen consumption change predicts left ventricular relaxation improvement in obese humans after weight loss. Obesity (Silver Spring). 2011 Sep;19(9):1804-12. PMID: 21738241.

Nekouzadeh A, Rudy Y. Three-residue loop closure in proteins: a new kinematic method reveals a locus of connected loop conformations. J Comput Chem. 2011 Sep;32(12):2515-25. doi: 10.1002/jcc.21812. Epub 2011 May 26. PubMed PMID: 21618253.

Peterson LR, Saeed IM, McGill JB, Herrero P, Schechtman KB, Gunawardena R, Recklein CL, Coggan AR, Demoss AJ, Dence CS, Gropler RJ. Sex and Type 2 Diabetes: Obesity-Independent Effects on Left Ventricular Substrate Metabolism and Relaxation in Humans. Obesity (Silver Spring). 2011 Aug 4. [Epub ahead of print] PMID: 21818149.

Shao JS, Sierra OL, Cohen R, Mecham RP, Kovacs A, Wang J, Distelhorst K, Behrmann A, Halstead R, Towler DA. Vascular Calcification and Aortic Fibrosis: A Bifunctional Role for Osteopontin in Diabetic Arteriosclerosis. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1821-33., (2011). PMID: 21597007.

Schilling JD, Lai L, Sambandam N, Dey C, Leone TL, and Kelly DP. Toll-like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-activated receptor g Coactivator-1 (PGC-1) Signaling. Circ Heart Fail. 2011 Jul 1;4(4):474-482. PMCID: PMC3144030.

Musselman LP, Fink JL, Narzinski K, Ramachandran PV, Hathiramani SS, Cagan RL, Baranski TJ. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis Model Mech. 2011 Jun 30. [Epub ahead of print] PMID: 21719444.

Gaur N, Rudy Y. Multiscale modeling of calcium cycling in cardiac ventricular myocyte: macroscopic consequences of microscopic dyadic function. Biophys J. 2011 Jun 22;100(12):2904-12. PubMed PMID: 21689523; PMCID: PMC3123916.

Nekouzadeh A, Rudy Y. Continuum molecular simulation of large conformational changes during ion-channel gating. PLoS One. 2011;6(5):e20186. Epub 2011 May 20. PubMed PMID: 21625456; PMCID: PMC3098872.

T.J. O’Hara, L. Virág, A. Varró, Y. Rudy, “Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation” PLoS Comput Biol. 2011 May; 7(5):e1002061. PMCID: PMC3102752.

Cotter DG, d'Avignon DA, Wentz AE, Weber ML, Crawford PA. Obligate role for ketone body oxidation in neonatal metabolic homeostasis. J Biol Chem 2011 Mar 4;286(9):6902-10.

Cobley CM, Chen J, Cho EC, Wang LV, Xia Y. Gold nanostructures: a class of multifunctional materials for biomedical applications. Chem Soc Rev. 2011 Jan;40(1):44-56. Epub 2010 Sep 6. Review. PMID: 20818451.

Garbow JR, Doherty JM, Schugar RC, Travers S, Weber ML, Wentz AE, Ezenwajiaku N, Cotter DG, Brunt EM, Crawford PA. Hepatic steatosis, inflammation, and ER stress in mice maintained long-term on a very low-carbohydrate ketogenic diet. Am J Physiol Gastrointest Liver Physiol 2011 Mar 31 [Epub ahead of print] PMID: 21454445.

Anderson CC, Gibson AA, Schaffer JE, Peterson LR, Holland MR, Miller JG. “Bayesian parameter estimation for characterizing the cyclic variation of echocardiographic backscatter to assess the hearts of asymptomatic type 2 diabetes mellitus subjects”, Ultrasound Med Biol., 37(5): p. 805-812; (2011) PMC3078972.

Hoffman JJ, Johnson BL, Holland MR, Fedewa RJ, Nair A, Miller JG. “Layer-dependent variation in the anisotropy of apparent integrated backscatter from human coronary arteries.” Ultrasound Med Biol., 37(4): p. 632-641; (2011) PMC3063363.

Lloyd, C.W., Shmuylovich, L., Holland, M.R., Miller, JG, and Kovacs, S.J., The Diastolic Function to Cyclic Variation of Myocardial Ultrasonic Backscatter Relation: The Influence of Parameterized Diastolic Filling (Pdf) Formalism Determined Chamber Properties. Ultrasound Med Biol, 37(8): p. 1185-1195; (2011); PMC3129365.

McGill JB, Peterson LR, Herrero MS, Saeed IM, Recklein C, Coggan AR, DeMoss AJ, Schechtman KB, Dence CS, Gropler RJ. Potentiation of the abnormalities in myocardial metabolism with the development of diabetes in women with obesity and insulin resistance. J Nucl Cardiol 2011; 18:421-429.

Michel CI, Holley, CL, Scruggs BS, Sidhu, R, Brookheart RT, Listenberger LL, Behlke M, Ory DS, Schaffer JE (2011). Small nucleolar RNAs, U32, U33, and U35 are critical mediators of metabolic stress. Cell Metab 14(1), 33-44.Janardhan, A, Chen, J, Crawford PA. Altered systemic ketone metabolism in advanced heart failure. Tex Heart Inst J. 2011; 38(5):533-8.

Lindman BR, Arnold SV, Madrazo JA, Zajarias A, Johnson SN, Perez JE, Mann DL. The Adverse Impact of Diabetes Mellitus on Left Ventricular Remodeling and Function in Patients with Severe Aortic Stenosis. Circ Heart Fail. 2011;4:286-292.

R.J. van Oort, A. Garbino, W. Wang, S.S. Dixit, A.P. Landstrom, N. Gaur, A.C. De Almeida, D.G. Skapura, Y. Rudy, A.R. Burns, M.J. Ackerman, X.H.T. Wehrens, “Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors Following Acute Junctophilin Knockdown in Mice” Circulation 2011;123:979-988. J. Heijman, P.G.A. Volders, R.L. Westra, Y. Rudy, “Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient” J Mol Cell Cardiol 2011;50:863-871.

S. Ghosh, J.N.A. Silva, R.M. Canham, T.M. Bowman, J. Zhang, E.K. Rhee, P.K. Woodard, Y. Rudy, “Electrophysiological Substrate and Intraventricular LV Dyssynchrony in Non-ischemic Heart Failure Patients Undergoing Cardiac Resynchronization Therapy” Heart Rhythm 2011;8:692-699.

K. Acsai, G. Antoons, L. Livshitz, Y. Rudy, K. R. Sipido, “Microdomain [Ca2+] near ryanodine receptors as reported by L-type Ca2+ and Na/Ca exchange currents” J Phsiol 2011;589:2569-2583.

Schilling JD and Kelly DP. The PGC-1 Cascade as a Therapeutic Target for Heart Failure. J Mol Cell Cardiol. 2011, 51(4): 578-83. PMCID: PMC3042046.

Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG. Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial. Circulation. 2011; 124:1426-1434. PMCID: PMC3629972


Cuculich PS, Wang Y, Lindsay BD, Faddis MN, Schuessler RB, Damiano RJ Jr, Li L, Rudy Y. Noninvasive characterization of epicardial activation in humans with diverse atrial fibrillation patterns. Circulation. 2010 Oct 5;122(14):1364-72. PMID: 20855661; PMCID: PMC2996091.

Xie, J.; MacEwan, M.; Wilson, R.; Liu, W.; Daku, S. and Xia, Y. Radially aligned, electrospun nanofibers as dural substitutes for wound closure and tissue regeneration applications. ACS Nano 2010 Sept 28; 4(9):5027-5036. PMCID: PMC2947607; NIHMSID: NIHMS227879.

Wentz AE, d'Avignon DA, Weber ML, Cotter DG, Doherty JM, Kerns R, Nagarajan R, Reddy N, Sambandam N, Crawford PA. Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment. J Biol Chem 2010 Aug 6;285(32):24447-56.

Lloyd, C.W., Holland, M.R., and Miller, JG, Improving the Reproducibility of the Cyclic Variation of Myocardial Backscatter. Ultrasonic Imaging, 32(4): p. 243-254; (2010).

Holland MR, Gibson AA, Bauer AQ, Peterson LR, Schaffer JE, Bach RG, Cresci S, and Miller JG, “Echocardiographic Tissue Characterization Demonstrates Differences in the Left and Right Sides of the Ventricular Septum”, Ultrasound Med Biol., 36(10): pp. 1653-61; (2010) PMID: 20800946.

Chen, J.; Yang, M.; Zhang, Q.; Cho, E. C.; Cobley, C. M.; Claus, C.; Kim, C.; Wang, L. V.; Welch, M. J. and Xia, Y. Gold nanocages: A novel class of multifunctional materials for theranostic applications. Advanced Functional Materials 2010 20(21):3684-3694.

Cho, E. C.; Liu, Y. and Xia, Y. A simple spectroscopic method for differentiating cellular uptakes of gold nanospheres and nanorods from their mixtures. Angewandte Chemie International Edition 2010, 49, 1976-1980.

Xie, J.; MacEwan, M. R.; Schwartz, A. G. and Xia, Y. Electrospun nanofibers for neural tissue engineering. Nanoscale 2010, 2, 35-44 (invited feature article).

S. Ghosh, D.H. Cooper, R. Vijayakumar, J. Zhang, S. Pollak, M. Haissaguerre, Y. Rudy, “Early repolarization associated with sudden death: Insights from noninvasive Electrocardiographic Imaging (ECGI)” Heart Rhythm 2010;7(4):534-537.

Beitelshees AL, Finck BN, Leone TC, Cresci S, Wu J, Province MA, Fabbrini E, Kirk E, Zineh I, Klein S, Spertus JA, Kelly DP. Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes. Pharmacogenet Genomics. 2010; 20:231-238. PMCID: PMC2842450

Cresci S, Huss JM, Beitelshees AL, Jones PG, Minton MR, Dorn GW, Kelly DP, Spertus JA, McLeod HL. A PPAR promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes. PLoS ONE. 2010; 5:e12584. PMCID: PMC2933242


Gale SE, Westover EJ, Dudley N, Merlin S, Scherrer DE, Han X, Xiuhong Z, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, and Ory DS. Side-chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem. 2009 284:1755-1764; PMCID: PMC2615513.

Lange Y, Steck TL, Ye J, Lanier MH, Molugu V, and Ory DS. Regulation of a 27-hydrocholesterol-dependent sterol homeostatic pathway by active plasma membrane cholesterol. J Lipid Res, 2009, 50:1881-1888; PMCID: PMC2724788.

Flagg TP, Remedi MS, Haim TE, Tones, MA, Bahinski T, Numann R, Kovacs A, Schaffer JE, Nichols CG, Nerbonne JM. Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy. Circ Res 2009 104:95-103.

Brookheart RT, Michel CI, Listenberger LL, Ory DS, Schaffer JE. The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and ER stress. J Biol Chem 2009 284: 7446-7454.

Brookheart RT, Michel CI, Schaffer JE,. As a matter of fat. Cell Metabolism 2009 20: 9-12.

Liu L, Shi XJ, Bharadwaj KG, Ikeda S, Yamashita H, Yagyu H, Schaffer JE, Yu YH, Goldberg IJ. DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity. J Biol Chem 2009 284:36312-36323.

A. A. Gibson, J. E. Schaffer, L. R. Peterson, K. R. Bilhorn, K. M. Robert, T. A. Haider, M. S. Farmer, M. R. Holland and J. G. Miller. Quantitative analysis of the magnitude and time delay of cyclic variation of myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects. Ultrasound Med Biol, 35, p. 1458-1467. 2009. PMID: 19616360; PMCID: PMC2731824.

Yavuz, M. S.; Cheng, Y.; Chen, J.; Cobley, C. M.; Zhang, Q.; Rycenga, M.; Xie, J.; Kim, C. H.; Song, K. H.; Schwartz, A. G.; Wang, L. V. and Xia, Y. Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nature Materials 2009, 12, 935-939.

Sihag S, Cresci S, Li AY, Sucharov CC, Lehman JJ. PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol. 2009; 46:201-212. PMCID: PMC2681265


Zhang J, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands M, Schaffer JE, Semenkovich C and Ory DS. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. J Clin Invest 2008, 118: 2281-2290; PMCID: PMC2381744.

Cresci S, Jones PG, Sucharov CC, Marsh S, Lanfear DE, Garsa A, Courtois M, Weinheimer CJ, Wu J, Province MA, Kelly DP, McLeod HL, Spertus JA. Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. Pharmacogenomics. 2008; 9:1403-1417. PMCID: PMC2586954


O'Connor, R. D., Gropler, R. J., Peterson, L., Schaffer, J. Ackerman, J. J. H. Limits of a Localized Magnetic Resonance Spectroscopy Assay for Ex Vivo Myocardial Triacylglycerol, J Pharm Biomed Anal 2007, 45:382-389.


Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto TA, Ory DS, Schaffer JE. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol Biol Cell, 2006, 17:770-778.

Holland MR, Gibson AA, Peterson LR, Areces M, Schaffer JE, Perez JE, Miller JG. Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic cardiomyopathy. Journal of Cardiometabolic Syndrome 2006, 149-152.

Borradaile NM, Han X, Harp JD, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity is central to lipotoxic cell death. J Lipid Res, 2006 47: 2726-2737.

 2005 and earlier

Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of FATP1 in the heart causes lipotoxic cardiomyopathy. Circ Res, 2005, 96:225-233.

Listenberger LL, Han X, Lewis SL, Cases S, Farese RV, Ory DS, SchafferJE. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA, 2003, 100: 3077-3082.

Listenberger L.L., Ory D.S., Schaffer JE. Palmitate-induced apoptosis occurs through a ceramide-independent pathway. J Biol Chem 2001, 276: 14890-14895.

Chiu H-C., Kovacs A., Ford D.A., Hsu F.-F., Garcia R., Herrero P., Saffitz J.E., Schaffer JE. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest 2001, 107: 813-22.

Return to Top ^